Kaposi’s varicelliform eruption is a rare and potentially fatal viral infection caused mainly by reactivation of herpes simplex virus. It concomitantly occurs with. Disseminated herpes or vaccinia in the setting of underlying skin diseases is known as Kaposi’s varicelliform eruption (KVE). Patients typically present with. It is autosomal dominant in transmission. Patients with DWD are prone to frequent superinfection including the rare complication of Kaposi varicelliform eruption.

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A review of the literature reveals a diversity of opinion as to the etiological agent in Kaposi’s varicelliform eruption. Most patients achieve resolution of the skin lesions over several days.

Kaposi Varicelliform Eruption – StatPearls – NCBI Bookshelf

Some sources reserve the term “eczema herpeticum” when the cause is due to human herpes simplex virus[2] and the term “Kaposi varicelliform eruption” to describe the general presentation without specifying the virus. Kaposi’s varicelliform eruption eczema herpeticum is the name faricelliform to a distinct cutaneous eruption caused by herpes simplex and certain other viruses that infect persons with preexisting dermatosis.

High dose intravenous acyclovir is often necessary for disease control. Kapposi Kaposi’s varicelliform eruption in erythrodermic psoriasis.

The most commonly affected sites are head, neck, and trunk. Therefore, prophylactic antibiotic therapy is recommended. We present a case series that includes four adults, familial cases, and previously healthy patients.

National Center for Biotechnology InformationU. The incidence is not precisely known due to its rarity and the lack of large case series.

This article has been cited by. Views Read Edit View history. Fifteen cases were sporadic, whereas four were familial two cousins on one side and two siblings on the other. Retrieved from ” https: Patients with Kaposi varicelliform eruption present with a sudden skin eruption of painful clusters of umbilicated vesicles and pustules. Table 1 Clinical features of patients with Kaposi’s varicelliform eruption. We report a case of a three-year-old atopic child who presented with extensive vesicular eruption suggestive of Kaposi’s varicelliform eruption.


Virus-related cutaneous conditions Herpes simplex virus-associated diseases.

All patients were treated with oral or parenteral acyclovir with a dose ranging from to mg per day until complete resolutionwhereas in 10 patients, systemic antibiotic was added. Kaposi’s Varicelliform varlcelliform in a patient with healing peribucal dermabrasion. The diagnosis is mainly clinical. Differential diagnoses are chickenpox, impetigo, contact dermatitis,[ 1 ] and smallpox vaccine could also be done.

The Tzanck smear, viral cultures, skin biopsy, or detection of viral DNA by Polymerase Chain Reaction may be helpful in doubtful cases. However, adult cases have been reported. Parvovirus B19 Erythema infectiosum Reticulocytopenia Papular purpuric gloves and socks syndrome.

Harindra V, Paffett MC. A skin biopsy is not required to confirm a diagnosis, varicekliform if it is performed, histological findings include intra-epidermal blister, acantholysis, multinuclear giant cells with intranuclear inclusion, and ballooning degeneration of the keratinocytes.

Eczema herpeticum

Both cell-mediated and humoral immunity dysfunction are implicated. Wetzel S, Wollenberg A. The distribution of affected skin reflects the crucial role of skin barrier impairment since Kaposi varicelliform eruption begins in areas of underlying dermatosis.

Eczema herpeticum is caused by Herpes simplex virus HV1, the virus that causes cold sores; it can also be caused by other related viruses. Widespread clusters of vesicles and erosions covered by hemorrhagic crusts. In a clockwise direction: The head was the most commonly involved site, followed by trunk and limbs. Patient responded adequately to oral acyclovir therapy. It concomitantly occurs with pre-existing skin conditions, mostly atopic dermatitis, so it is predominately found in children.


Turn recording back on. We believe it is important to recognize this entity and to establish early treatment in order to avoid complications. Open in a separate window. Kaposi’s varicelliform eruption KVEalso known as eczema herpeticum,[ 1 ] is a rare and potentially fatal viral infection, caused mainly by reactivation of herpes simplex virus HSVpredominantly type I.

The diagnosis is clinical[ 1 ]. Kaposi varicelliform eruption may be associated with systemic symptoms such as malaise, high temperature, and swollen lymph nodes. Sign in to save your search Sign in to your personal account. Nucleoside analogs are the antiviral agents most commonly used since they inhibit viral DNA replication. In addition, the disease can be complicated by multiple organ involvements, mainly of the central nervous system, liver, lungs, gastrointestinal tract, and adrenal glands.

It is inexpensive, easily applicable, and quick to perform. J Am Acad Dermatol. Clear Turn Off Turn On. Fifteen were children and only four were adults, with a similar distribution in both sexes 9 females and 10 males. How to cite this URL: In fact, a histological examination may confirm a diagnosis that may not have been thought of clinically, whereas polymerase chain reaction will detect viral DNA by Polymerase Chain Reaction.

Another developed it while on extracorporeal photopheresis for Sezary syndrome. Histopathology A skin biopsy is not required to confirm a diagnosis, but if it is performed, histological findings include intra-epidermal blister, acantholysis, multinuclear giant cells with intranuclear inclusion, and ballooning degeneration of the keratinocytes.

In case of doubt, the Tzanck smear allows a diagnostic approach, that is rapid and economical,[ 14 ] though not specific.