CPSP, previously known as Dejerine-Roussy syndrome and thalamic pain syndrome, is a feared complication of cerebrovascular accidents and has been. Stroke and pain can sometimes result in Dejerine-Roussy syndrome. Available treatments include antidepressants, anticonvulsants, and. Due to the high clinical variability in presentation of Déjerine-Roussy syndrome, it is impossible to predict which patients with a thalamic stroke will develop pain.

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Symptoms are generally not treatable with ordinary analgesics. For example, affected individuals may experience pain when touched, even when lightly touched.

Dejerine Roussy Syndrome – StatPearls – NCBI Bookshelf

General Discussion Summary Central pain syndrome is a neurological disorder caused by damage to the sensory pathways of the central nervous system CNS. If antidepressants are not effective, an anticonvulsant like carbamazepine is added, especially if the pain is sharp and lancinating. Pain can fluctuate during the day and can be affected by several factors including touch, emotions such as stress, certain movements or overall level of activity, and temperature changes, especially cold temperatures.

In general, strokes damage one hemisphere of the brain, which can include the thalamus.

Epub Aug Migraine Familial hemiplegic Cluster Tension. Affected individuals may become hypersensitive to painful stimuli. During this surgical procedure, an electrode is placed into the thalamus and a thin wire is passed under the skin is connected to a small battery pack which is also placed underneath the skin.


The onset dejdrine pain symptoms may vary from days to years after having a stroke.

Newer pharmaceuticals include anti-convulsants and Kampo medicine. The last 50 years have been filled with refractory treatment research. Dejerine-Roussy is a rare pain syndrome. Review Central poststroke pain: Exploration of each of these topics led to a definition of neurologic semiology and to the development of neurophysiology during the second half of the XXth century. The location of the pain also varies considerably, and can affect a large part of the contralateral body or a smaller portion depending on the exact size and location of the thalamic lesion About Blog Go ad-free.

Pain is relieved after 4 to 7 days of reaching the optimal dose. Stroke affecting the lateral thalamus causes central disinhibition by the deafferentation of the thalamic nucleus, which causes the activation of cortical areas resulting in pain.

Rare Disease Database

Antiplatelet medications especially cilostazol may have a role in the treatment of central post-stroke pain. Diagnosis and assessment of neuropathic pain. Extradural cortical stimulation for central pain. In the past, surgery has been used to treat sndrome with central pain syndrome. Another proposed pathway of central imbalance is at the level of third level neurons of the spinothalamic pathway. The name Dejerine—Roussy syndrome was coined after their deaths.

Many chemical medications have been used for a broad range of neuropathic pain including Dejerine—Roussy syndrome. Diffusion tensor tractography DTT shows a 3-dimensional view and estimation of the function of the spinothalamic tract. Epub Jul 3. Central pain syndrome is a neurological disorder caused by damage to the sensory pathways of the central nervous system Rousys. Expert Review of Neurotherapeutics. The imbalance in sensation characterized by Dejerine—Roussy syndrome can be argued through a model addressing a system of inputs and outputs that the brain must constantly syndroje throughout life, suggesting latent plasticity.


Additionally, therapies that have proven beneficial in some individuals may have no benefit in others. The revision of the thalamic syndrome ceased when the discovery of the non-specific functions of the thalamus opened the symdrome to new concepts.

Epub Feb Discussion pertaining to radiographic features of ischemic strokes and hemorrhagic strokes is discussed in dejerinw depth elsewhere see individual articles.

It is an option of treatment in a limited number of patients. Information on current clinical trials is posted on the Internet at www. Differential Diagnosis Cervical disk herniation.

The alleviated symptoms may include reduction in spasticity and reduction in chronic post-stroke pain. Confirmation of a central nervous system lesion through imaging or negative or positive sensory signs confined to the area of the body corresponding to the lesion.

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