extract of Glycyrrhiza glabra Linn. in aspirin induced ulcer in rats. . The aim of the study was to determine anti ulcer activity of stem bark of. Anti-ulcer activity was evaluated by measuring the ulcer index, gastric content, total Keywords: Anti-ulcer, Cold-restraint, Glycyrrhiza glabra, GutGardTM. The present research has been carried out to investigate antiulcer activity of ethanolic extract of Cynodon dactylon, Ocimum sanctum, Glycyrrhiza glabra, Ficus.

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Open Access Glabrx Access. Four hours after indomethacin administration, animals were euthanized by cervical dislocation. Stomach was opened along the greater curvature then ulceration index was determined examining the inner lining of stomach. To overcome the drawbacks, many experimental investigations 2357 have been undertaken to detect and develop ulcer healing agents by various plant origin compounds.

Indomethacin a non-steroidal anti-inflammatory agents, decrease cyclooxygenase activity and then production of endogenous prostaglandin levels in the gastric mucosa 20leading to gastric hypermotility and vascular disturbances, thus stimulating the activation of reactive oxygen species ROS production, lipid peroxidation and infiltration of neutrophils Gastric mucosal cellular changes induced by indomethacin male albino rats.

Agri and Aquaculture Journals Dr. Ethanol and HCl are corrosive agents that damage the gastric mucosa. The animals were randomly achivity to different groups. Ulcer index was calculated following the method described previously 9. All treatments were performed by gavage. Animals The study was conducted on Swiss mice of either sex, weighing 25—30 g.

Introduction The genus glycyrrhiza consists of approximately 30 species, in which six species produce a sweet saponin glycyrrhizic acid GAthat is widely used in the confectionery and pharmaceutical industries in various countries 1.


Anti Ulcer Activity Of Aloevera And Glycyrrhiza Glabra In Swiss Albino Rats |

Many drugs are in the market to treat ulcer, but they have lot of adverse effects. HEGG reduced the ulcer index in hypothermic stress induced gastric ulcers glycyrrhjza mice and the antiulcer effect was comparable to that of cimetidine. The hydroalcoholic extract of Glycyrrhiza glabra L.

Currently, effective drugs exist for peptic ulcer diseases. Ulcer index UI and Preventive Index PI of each of the groups was calculated using standard methods as described above. Recently it was shown that licorice in a combination product could heal ulcers effectively 33 that strongly confirm results of this study. This model, cold restraint stress-induced gastric ulcers, has been used due to data reproducibility and similarity with human gastric ulcers to evaluate the effect of drugs on gastric secretion, stress and gastrointestinal motility.

Find articles by Ehsan Anassori. Several flavonoids, present in different plants are known to reduce gastric ulcer formation Use of combination of herbal drugs proved that these are effective alternatives for chemical drugs.

The authors gratefully appreciate the financial support by the faculty of Veterinary Medicine Urmia University, Iran. Antiulcer activity of Sapindus saponaria L. Flavonoids liquritin, glabrolisoflavones glabrene, glabridinchalcones isoliquiritinantjulcer liquocoumarin and stilbenoides besides minor amounts of essential oil and polysaccharides are compounds detected in liquorice root 3.

Pharmaceutical Sciences Journals Ann Jose ankara escort. Preventive anti-ulcer activity and toxicity of the leaf crude extract.

Gastric contents and blood clots were removed then the stomach rinsed in formaldehyde and fixed between two glass plates. Besides, being a popular food additive, licorice is also one of the most widely used medicinal herbs in Iran. The creation of ethanol-induced gastric lesions is of multifactorial origin with decrease in gastric mucus amount as one of the involved factors. Iran J Pharm Res. Licorice compounds glycyrrhizin and 18beta-glycyrrhetinic acid are potent modulators of bile acid-induced cytotoxicity in rat hepatocytes.


The stomachs were gently rinsed with water to remove the gastric contents and blood clots, for subsequent examination. The constituent s responsible for antiulcer effect of G. A voucher specimen number was kept in the herbarium.

Received Feb; Accepted Jun. Gastroduodenal ulcer protective activity of Asparagus racemosus: The ulcer index was The HEGG protected the stomachs of the mice from induced acute ulceration in various models and did not present acute toxic effects, providing scientific support to the traditional use of this plant.

Anti-ulcer activity of aqueous and ethanolic extracts of Glycyrrhiza glabra L. in rats.

Ulcer index and preventive index of each of the groups was calculated using standard methods as described above. Oral treatment with indomethacin developed considerable ulcers in the glandular portion of stomach.

Articles from Iranian Journal of Pharmaceutical Research: The antioxidant properties of flavonoids and tannins have been related to anti-ulcer activity 31 since free radicals are developed in gastric mucosal lesions. HEGG inhibit formation of ulcers in all four models and at all doses significantly.

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